Santiago Pérez may refer to:
Santiago Pérez de Manosalbas (1830–1900), president of Colombia Santiago Pérez Eastman (1858–1925), Chilean farmer and politician Santiago Pérez Peña (born 1883), Chilean engineer and politician Santiago Pérez (racewalker) (born 1972), Spanish racewalker Santiago Pérez (baseball) (born 1975), Dominican baseball player Santiago Pérez (cyclist) (born 1977), Spanish cyclist Santiago Pérez (footballer) (born 1998), Uruguayan footballer
See also Santiago Pérez Quiroz Airport, in Cauca, Colombia