Papakonstantinou () is a Greek surname. It means "The Family of Father Constantine" (father referring to the priesthood). It is the surname of:
Alex P Alexander "Alex P" Papaconstantinou, Greek-Swedish songwriter and music producer Anastasios Papakonstantinou (born 1963), Greek bobsledder Anthi Papakonstantinou (born 1995), Greek footballer Elli Papakonstantinou, stage director, librettist, translator and activist Giorgos Papakonstantinou (born 1961), Greek finance minister Michalis Papakonstantinou, (1919–2010), Greek politician, Minister for Foreign Affairs Thanassis Papakonstantinou (born 1959), Greek folk-rock singer and songwriter Theofylaktos Papakonstantinou (1905–1991), Greek journalist, writer and politician Vasilis Papakonstantinou (born 1950), Greek rock singer Frini Papakonstantinou, (born 1994), Greek educator