High and Mighty may refer to:
In music: High and Mighty (album), an album by Uriah Heep High & Mighty, an album by Gov't Mule High and Mighty (band), an American rap duo
In other uses: High and Mighty (book), a nonfiction book about SUVs by Keith Bradsher High and Mighty (shop), a UK big-and-tall menswear retail outlet
See also High and Mighty Color, a Japanese J-rock band The High and the Mighty (disambiguation)