Margherita Gonzaga may refer to: Margherita Malatesta (1370–1399), wife of Francesco I Gonzaga Margherita Gonzaga, Marquise of Ferrara (1418–1439), first wife of Leonello d'Este, Marquis of Ferrara Margaret of Bavaria, Marchioness of Mantua (1442–1479), the wife of Federico I Gonzaga, Marquess of Mantua Margherita Gonzaga (1496–1496), daughter of Isabella d'Este and Francesco Gonzaga Margherita Paleologa (1510–1566), wife of Federico II Gonzaga Margherita Gonzaga, Duchess of Ferrara (1564–1618), also known as Margherita Gonzaga d'Este Margherita Farnese (1567–1643), wife of Vincenzo Gonzaga, Duke of Mantua Margaret of Savoy, Vicereine of Portugal (1589–1655), wife of Francesco IV Gonzaga Margherita Gonzaga, Duchess of Lorraine (1591–1632), eldest daughter of Vincenzo I Gonzaga and Eleonora de' Medici