Trimetrexate is a quinazoline derivative. It is a dihydrofolate reductase inhibitor.
Uses It has been used with leucovorin in treating pneumocystis pneumonia.
It has been investigated for use in treating leiomyosarcoma. It is a methotrexate (MTX) analog that is active against transport-deficient MTX-resistant tumor cells that overcome the acquired and natural resistance to methotrexate. Other uses include skin lymphoma. Trimetrexate in relapsed T-cell lymphoma with skin involvement. J Clin Oncol. 2002 Jun 15;20(12):2876-80.
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