Grissom is a surname. Notable people bearing it include:
Barry Grissom (born 1954), former U.S. Attorney Betty Grissom (1927–2018), American plaintiff Clayton Holmes Grissom (born 1978), American pop singer Clay Aiken, made famous by American Idol Cory Grissom (born 1990), American football player Daniel M. Grissom (1829–1930), American journalist David Grissom (fl. from 1978), American session guitarist Geneo Grissom (born 1992), American football player Gus Grissom (1926–1967), the second American astronaut to fly in space; killed in the Apollo 1 accident Irene Welch Grissom (1873–1965), American poet Janet G. Mullins Grissom (1949–2023), American lobbyist Lauren Grissom (born 1985), American beauty queen Lee Grissom (1907–1998), American baseball player Marquis Grissom (born 1967), American baseball player and coach Marquis Grissom Jr. (born 2001), American baseball player Marv Grissom (1918–2005), American baseball pitcher and coach Richard Grissom (born 1960), American serial killer Steve Grissom (born 1963), American stock car racing driver Toney Grissom (born 1837/38), American Baptist minister, farmer and politician Vaughn Grissom (born 2001), American baseball player
Fictional characters Carl Grissom, a character and crime lord in Batman Gil Grissom of CSI: Crime Scene Investigation Cyrus Grissom of Con Air