Pymatuning can refer to several places in the U.S. States of Ohio and Pennsylvania:
Ohio Ashtabula County Pymatuning State Park (Ohio) Pymatuning Valley High School
Pennsylvania Crawford County Pymatuning Central, Pennsylvania, a census-designated place Pymatuning North, Pennsylvania, a census-designated place Pymatuning South, Pennsylvania, a census-designated place Pymatuning State Park (Pennsylvania) Pymatuning Laboratory of Ecology, the ecology field station of the University of Pittsburgh
Mercer County Pymatuning Township, Pennsylvania South Pymatuning Township, Pennsylvania
Ohio and Pennsylvania Pymatuning Reservoir, a man-made lake Pymatuning Creek, a tributary of the Shenango River