James Duff may refer to:
Politicians Sir James Duff (British Army officer) (1752–1839), British army officer, who fought in the Napoleonic wars and a Member of Parliament James Grant Duff (1789–1858), Indian soldier and statesman James Duff (North Norfolk MP) (1831–1878), British MP for North Norfolk James Stoddart Duff (1856–1916), Canadian politician James Augustine Duff (1872–1943), Ulster Unionist politician in Northern Ireland James H. Duff (1883–1969), Pennsylvanian politician James Duff, 2nd Earl Fife (1729–1809), MP for Banffshire and Elginshire James Duff, 4th Earl Fife (1776–1857), MP for Banffshire James Duff, 5th Earl Fife (1814–1879), MP for Banffshire
Others Sir James Duff, 1st Baronet (died 1815), of the Duff-Gordon baronets James Duff Duff (1860–1940), English translator and classical scholar James Fitzjames Duff (1898–1970), British educationalist James Duff (businessman) (born 1961), American billionaire businessman James Duff (writer) (born 1955), American screenwriter and playwright James C. Duff (born 1953), Director of the Administrative Office of the United States Courts
See also Jamie Duff (born 1989), Scottish association football player