Family Guy is an American adult animated sitcom created by Seth MacFarlane for the Fox Broadcasting Company. The series centers on the Griffins, a family consisting of parents Peter and Lois; their children Meg, Chris, and Stewie; and their anthropomorphic pet dog Brian. The show is set in the fictional city of Quahog, Rhode Island, and exhibits much of its humor in the form of cutaway gags that often lampoon American culture. Along with its core voice actors, episodes make frequent use of guest stars.

Guest stars who have lent their voices to the show come from a wide range of occupations including musicians, actors, athletes, politicians, scientists and more. Some have only made a single appearance, while others like James Woods and Ryan Reynolds have gone on to become recurring fan favorites. Over the years, the show has become notable for featuring actors reprising their roles in animated form. In the episode "Lois Comes Out of Her Shell", for example, Johnny Depp reprised his iconic role as Edward Scissorhands. Most early guest stars appeared less as characters and more as themselves, with musician Waylon Jennings being the first to do so in the episode "Chitty Chitty Death Bang". Furthermore, in "Not All Dogs Go to Heaven", the entire main cast of Star Trek: The Next Generation–including Patrick Stewart, Jonathan Frakes, Brent Spiner, LeVar Burton, Gates McFadden, Michael Dorn, Wil Wheaton, Marina Sirtis, and even Denise Crosby (season 1 as Tasha Yar)–appear as themselves headed to a Star Trek convention.

Season 1 Name Role(s) EpisodeErik EstradaPonch"I Never Met the Dead Man"Episode 2Frank WelkerFred JonesJohn O'HurleyCult leader"Chitty Chitty Death Bang"Episode 3Waylon JenningsHimselfAlex RoccoSoccer parent"Mind Over Murder"Episode 4Leslie UggamsHerselfMichelle KwanHerself"A Hero Sits Next Door"Episode 5Bobby SlaytonLeonard Cornfeathers"The Son Also Draws"Episode 6Mary ScheerAnn LandersMaryMother"Brian: Portrait of a Dog"Episode 7Dick Van PattenTom Bradford

Season 2 Name Role(s) EpisodeFairuza BalkConnie D'Amico"Peter, Peter, Caviar Eater"Episode 1Gregory JbaraJonathanRobin LeachHimselfCharles DurningFrancis Griffin"Holy Crap"Episode 2Olivia HackCindy BradyDwight SchultzThe PopeFlorence StanleyThelma GriffinPatrick DuffyBobby Ewing"Da Boom"Episode 3Jack PerkinsHimselfVictoria PrincipalPamela EwingWill SassoRandy NewmanSam WaterstonDr. Kaplan"Brian in Love"Episode 4Debra WilsonMrs. KranerSandy Belford"Love Thy Trophy"Episode 5Karen BlackHerself"Death Is a Bitch"Episode 6Norm MacdonaldDeathCandice BergenGloria Ironbachs"I Am Peter, Hear Me Roar"Episode 8Faith FordSarah Bennett, Corky SherwoodMartin MullMr. Harris"If I'm Dyin', I'm Lyin'"Episode 9James CarvilleHimself"Running Mates"Episode 10Lee MajorsHimselfDwight SchultzRandall FargusJack Sheldon'Vagina Junction' conductorCandice BergenMurphy Brown"A Picture is Worth 1,000 Bucks"Episode 11Charles KimbroughJim DialJoe RegalbutoFrank FontanaBullEditorBrian Doyle-MurrayLuke"Road to Rhode Island"Episode 13Victoria PrincipalDr. Amanda RebeccaGregg AllmanHimself"Let's Go to the Hop"Episode 14Mo CollinsDaycare teacherStewardess"Dammit Janet!"Episode 15Haley Joel OsmentLeonardDaycare kidCamryn ManheimBradMichael ChiklisBig Fat Paulie"There's Something About Paulie"Episode 16Robert CostanzoBiffLouieJon CryerKevinAlan KingThe DonJay MohrLogan"He's Too Sexy for His Fat"Episode 17Shawn PyfromOliver"E. Peterbus Unum"Episode 18Luke PerryHimself"The Story on Page One"Episode 19Adam CarollaDeath"Wasted Talent"Episode 20Michael McKeanPawtucket PatJulia SweeneyWoman in bar

Season 3 Name Role(s) EpisodeJune ForayRocket J. Squirrel"The Thin White Line"Episode 1Leif GarrettHimselfHaley Joel OsmentKid in bathroomLouise DuArtJoan Rivers"Brian Does Hollywood"Episode 2Olivia HackMelissa RiversJenna JamesonHerselfRon JeremyHimselfRay LiottaZackRicky BlittAlyssa Milano's lawyer"Mr. Griffin Goes to Washington"Episode 3Alyssa MilanoHerselfJack SheldonThe BillEd AsnerBrown-Haired Prisoner"One If By Clam, Two If By Sea"Episode 4Hugh LaurieBar patronPatrick DuffyJackSalesmanTeacher"And the Wiener Is..."Episode 5Adam CarollaDeath"Death Lives"Episode 6Estelle HarrisDeath's motherPeter FramptonHimselfLaura SilvermanAmyMichael ChiklisBronx guy #1"Lethal Weapons"Episode 7Peter GallagherJaredHugh DownsHimself"The Kiss Seen Around the World"Episode 8Josh PeckCharlieAbe VigodaHimselfAdam CarollaDeath"Mr. Saturday Knight"Episode 9R. Lee ErmeyCoachWill FerrellThe Black KnightJimmy KimmelDeath's dogMan in suitRenaissance guyMichael ChiklisHennessey"A Fish Out of Water"Episode 10Brian Doyle-MurraySaltyMajel BarrettShip computer"Emission Impossible"Episode 11Carol KaneCarolWallace ShawnBertramDakota FanningLittle girl"To Love and Die in Dixie"Episode 12Waylon JenningsHimselfKathleen WilhoiteSamBob BarkerHimself"Screwed the Pooch"Episode 13Don LaFontaineFOX AnnouncerMeredith Scott LynnBrenda"Peter Griffin: Husband, Father...Brother?"Episode 14Valerie BertinelliHerself as Bonnie Swanson"Ready, Willing, and Disabled"Episode 15Tony DanzaHimself as Joe SwansonAlex RoccoBea Arthur as Peter GriffinKISS Peter Criss Ace Frehley Gene Simmons Paul StanleyThemselves"A Very Special Family Guy Freakin' Christmas"Episode 16Fred WillardDave Campbell"From Method to Madness"Episode 18Jennifer Love HewittHerself"Stuck Together, Torn Apart"Episode 19Andy DickHimself"Road to Europe"Episode 20Jon FavreauDonny SciberraFirst bazaar salesmanLauren GrahamMother MaggieKISSThemselvesJane LynchDotty CampbellMichael McKeanPengrove PigAndy RooneyCamel salesmanFred WillardDave CampbellAdam CarollaDeath"Family Guy Viewer Mail 1"Episode 21Bill GoldbergBrawny guy on busRegis PhilbinHimselfKelly RipaHerselfMichael WinslowHimselfRicky BlittMordecai"When You Wish Upon a Weinstein"Episode 22Ed McMahonHimselfMark HamillLuke SkywalkerObi-Wan KenobiPeter RiegertMax WeinsteinBen SteinRabbi Goldberg

Season 4 Name Role(s) EpisodeHunter GomezPinocchio"North by North Quahog"Episode 1Don LaFontaineHimselfAndré SogliuzzoMel GibsonChris TuckerHotel managerDrew BarrymoreMrs. Lockhart"Fast Times at Buddy Cianci, Jr. High"Episode 2Arif S. KinchenCarlosHugh LaurieTV presenterSteven ZirnkiltonHimselfGina GershonPolicewoman"Blind Ambition"Episode 3Judd HirschHimselfJimmy IovineHimself"Don't Make Me Over"Episode 4Gene SimmonsHimselfPrisoner #3Jane CarrEndora"The Cleveland-Loretta Quagmire"Episode 5Mariam FlynnSamanthaFred TatascioreRandy SavageLeVar BurtonVern"Petarded"Episode 6Cloris LeachmanHerselfNatasha MelnickRuth CochamerMichael YorkBritish manJessica BielBrooke"Brian the Bachelor"Episode 7John ErwinHe-ManNancy CartwrightCasey Kelp Daffney GriffinDrew PinskyThe DermatologistJoanna GarcíaLiddane"8 Simple Rules for Buying My Teenage Daughter"Episode 8Brian TochiHelicopter pilot"Breaking Out Is Hard to Do"Episode 9Michael DornWorf"Peter's Got Woods"Episode 11Jonathan FrakesWilliam RikerPatrick StewartJean-Luc PicardGabrielle UnionShauna ParksJames WoodsHimselfAdam CarollaDeath"Perfect Castaway"Episode 12Jenna von OÿRoryCarrie FisherAngela"Jungle Love"Episode 13Mía MaestroLocaJay MohrJoe PesciBob BarkerHimself"The Fat Guy Strangler"Episode 17Robert Downey Jr.Patrick PewterschmidtWill SassoToddPaula AbdulHerself"The Father, the Son, and the Holy Fonz"Episode 18Tom BosleyHoward CunninghamSherman HemsleyHimselfMarion RossMarion CunninghamSarah UtterbackLindsay LohanMark BorchardtHimself"Brian Sings and Swings"Episode 19Frank Sinatra Jr.HimselfJeff BergmanFred Flintstone"Patriot Games"Episode 20Tom BradyHimselfTroy BrownHimselfCarol ChanningHerselfBob CostasHimselfJay LenoHimselfAlexander SiddigOne of the London Silly NanniesAdam CarollaDeath"I Take Thee Quagmire"Episode 21Bryan CranstonHalBeth LittlefordJane KaczmarekMother at parkChristy Carlson RomanoQuagmire's one-night standAlex TrebekHimselfWallace ShawnBertram"Sibling Rivalry"Episode 22Chris WedgeScratKate JacksonMrs. King"Deep Throats"Episode 23Frank WelkerFred JonesKermit the FrogTamera MowryBook customer"Peterotica"Episode 24Betty WhiteHerselfStark SandsJustin Hackeysack"You May Now Kiss the...Uh...Guy Who Receives"Episode 25Bob CostasHimself"Petergeist"Episode 26Carrot TopHimselfJudith LightHerself"Untitled Griffin Family History"Episode 27Drew BarrymoreHerself"Stewie B. Goode"Episode 28Noel BlancElmer FuddRon LivingstonVideo store clerkRené AuberjonoisOdo"Bango Was His Name, Oh!"Episode 29Jennie GarthKelly TaylorLarry KenneyLion-OLynne LiptonCheetaraJason PriestleyBrandon WalshTori SpellingDonna MartinJoy BeharHerself"Stu and Stewie's Excellent Adventure"Episode 30Michael Clarke DuncanStorkKiefer Sutherland24 opening narrator

Season 5 Name Role(s) EpisodeEllen Albertini DowElderly woman"Stewie Loves Lois"Episode 1Phyllis DillerThelma Griffin"Mother Tucker"Episode 2Tamera MowryEstherGore VidalHimselfLouis Gossett Jr.Himself"Saving Private Brian"Episode 4Samm LevineJoeyDrew BarrymoreJillian"Whistle While Your Wife Works"Episode 5Carrie FisherAngelaDrew BarrymoreJillian"Prick Up Your Ears"Episode 6David CrossJerry KirkwoodDrew BarrymoreJillian"Chick Cancer"Episode 7Jillian"Barely Legal"Episode 8Garrett MorrisHeadmaster of the New York School for the Hard of HearingTamera MowryEstherBill FagerbakkePatrick Star"Road to Rupert"Episode 9Gene KellyJoseph BradyTom KennySpongeBob SquarePantsRob LoweStanford CordrayGeorge WendtNorm PetersonPhyllis DillerThelma Griffin"Peter's Two Dads"Episode 10Charles DurningFrancis GriffinTamera MowryWaitressKeir GilchristKyle"The Tan Aquatic with Steve Zissou"Episode 11Hugh HefnerHimself"Airport '07"Episode 12Roy ScheiderHimself"Bill and Peter's Bogus Journey"Episode 13Conway TwittyHimselfPatrick StewartPeter Griffin with Patrick Stewart's voice"No Meals on Wheels"Episode 14Ben StillerHimselfDrew BarrymoreJillian"Boys Do Cry"Episode 15Bill EngvallDuke DillonGilbert GottfriedHorseNeil Patrick HarrisBarney Stinson"No Chris Left Behind"Episode 16Josh RadnorTed MosbyAshley FerlHerself"It Takes a Village Idiot, and I Married One"Episode 17Don MostHimselfKeith OlbermannBob GrossbeardAdam CarollaDeath"Meet the Quagmires"Episode 18

Season 6 Name Role(s) EpisodeChevy ChaseClark Griswold"Blue Harvest"Episode 1Beverly D'AngeloEllen GriswoldMick HucknallHimselfRush LimbaughHimselfJudd NelsonJohn BenderLeslie NielsenDr. RumackHelen ReddyHerselfDrew BarrymoreJillian"Movin' Out (Brian's Song)"Episode 2Jeff BergmanHomer SimpsonJamie FarrHimself"Believe It or Not, Joe's Walking on Air"Episode 3Paula AbdulHerself"Lois Kills Stewie"Episode 5Simon CowellHimselfRandy JacksonHimselfPatrick StewartAvery BullockPhyllis DillerThelma Griffin"Padre de Familia"Episode 6Alex FernandezGerardoCarrie FisherAngelaGabriel IglesiasMexican #5Jeff BergmanFred Flintstone"Peter's Daughter"Episode 7Pat Crawford BrownSanka dancerConway TwittyHimselfRicardo MontalbánThe Cow"McStroke"Episode 8Barry ManilowHimself"Back to the Woods"Episode 9David Van DamDavid LettermanJames WoodsHimselfChace CrawfordDylan"The Former Life of Brian"Episode 11Harvey FiersteinTracyAmanda BynesAnna"Long John Peter"Episode 12

Season 7