Michelini is an Italian surname, derived from the given name Michele. Notable people with the surname include:
Alberto Michelini (born 1941), Italian journalist and politician Arturo Michelini (1909–1969), Italian politician Danilo Michelini (1917–1983), Italian footballer Famiano Michelini (1604–1665), Italian mathematician Flavien Michelini (born 1986), French footballer Gian Carlo Michelini (1935–2026), Italian-Taiwanese Roman Catholic priest Giovanni Battista Michelini (1604–1655), Italian painter Giulia Michelini (born 1985), Italian actress Ottavio Michelini (1906–1979), Italian Roman Catholic priest Rafael Michelini (born 1958), Uruguayan politician Stéphanie Michelini, French actress Zelmar Michelini (1924–1976), Uruguayan reporter and politician