Ziffer is a surname. Notable people with the surname include:
Benny Ziffer (born 1953), Israeli writer and journalist Frances Ziffer (1917–1996), American composer, conductor and pianist Irit Ziffer (born 1954), Israeli archaeologist and art historian Moshe Ziffer (1902–1989), Israeli artist and sculptor Sándor Ziffer (1880–1962), Hungarian painter Tommaso Ziffer, Italian architect and interior designer Wolfgang Ziffer (1941–2022), German actor