AP1 or AP-1 may refer to:

Biology Activator protein 1, dimeric transcription factor Adaptor protein 1, tetrameric clathrin-associated complex

Transportation Autopista AP-1, a Spanish motorway Caproni A.P.1, a 1934 Italian attack aircraft monoplane USS Henderson (AP-1) Honda S2000 (AP1), a sports car

Other uses Protocol I, or AP 1, a 1977 amendment to the Geneva Conventions

See also API (disambiguation)