Route 57 is a name of roads and highways in many countries.

Route 57 may also refer to:

Route 57 (MTA Maryland), a bus route in metropolitan Baltimore, Maryland, U.S. Route 57 (MBTA), a bus route in Massachusetts, US London Buses route 57, England Melbourne tram route 57, Australia National Cycle Route 57, of the National Cycle Network, England Route 57 (magazine), an English online literary magazine