KCS may refer to:

Schools Kanawha County Schools, West Virginia Kennet School, a state school in south east England Kihei Charter School, in Kihei, Maui, Hawaii King's College School, an independent day school in south west London, England King's College School, a day school in Madrid, Spain operated by King's Group Kingsford Community School, an east London secondary school

Science and technology Keratoconjunctivitis sicca Killed carbon steel kilocycles per second, another name for kilohertz Kansas City standard, a standard for encoding binary data on tape used by many early microcomputers Knowledge-centered support, a service delivery method Keyboard Controller Style, an interface often used in the Intelligent Platform Management Interface architecture Korean Chemical Society Very-long-chain 3-oxoacyl-CoA synthase, an enzyme

Other Czechoslovak koruna, a unit of currency abbreviated Kcs Clinical Centre of Serbia, a medical center in Serbia, third largest in the world Kansas City Southern Railway, an American railroad Kansas City Southern (company), its parent company from 1887 to 2023 KCSF, formerly KCS radio station King's Colour Squadron, the unit of the Royal Air Force that safeguards the King's Colour