2-Phosphoglyceric acid (2PG), or 2-phosphoglycerate, is a glyceric acid which serves as the substrate in the ninth step of glycolysis. It is catalyzed by enolase into phosphoenolpyruvate (PEP), the penultimate step in the conversion of glucose to pyruvate.
2-Phosphoglyceric acid is an intermediate that is part of the glycolysis pathway, and it is converted into phosphoenolpyruvate (PEP) by an enolase. There are three types of enolase enzymes that are able to catalyze the conversion of 2-phosphoglyceric acid into PEP, which are alpha-enolase, beta-enolase, and gamma-enolase. Studies have found that alpha-enolase is the most common enolase, so it is often the specific enolase used to convert 2-phosphoglyceric acid into PEP. Alpha-enolase catalyzes this conversion process by acting as a hydrolase, which means that alpha-enolase removes a water molecule from the 2-phosphoglyceric acid in order to form PEP.
In glycolysis 3-phospho--glycerate Phosphoglyceromutase 2-phospho--glycerate Enolase phosphoenolpyruvate H2O H2O Phosphoglyceromutase Enolase
See also 3-Phosphoglyceric acid
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