Phosphoenolpyruvate carboxykinase (diphosphate) () is an enzyme with systematic name diphosphate:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming). This enzyme catalyses the following chemical reaction
diphosphate + oxaloacetate phosphate + phosphoenolpyruvate + CO2
This enzyme also catalyses the reaction: phosphoenolpyruvate + GTP + CO2 pyruvate + GDP.
It is transcriptionally upregulated in the liver by glucagon.
See also Phosphoenolpyruvate carboxykinase
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