Hippocalcin is a protein that in humans is encoded by the HPCA gene.
Hippocalcin is a calcium-binding protein that belongs to the neuronal calcium sensor (NCS) family of proteins. It is expressed in mammalian brains especially in the hippocampus. It possesses a Ca2+/myristoyl switch.
Processes
Hippocalcin takes part in the following processes:
Activation of PLD1 and PLD2 expression Inhibition of apoptosis MAP kinase signalling Involved in long term depression in hippocampal neuron Required for normal spatial learning
Interactions
Hippocalcin interacts with following proteins:
Neuronal apoptosis inhibitory protein (NAIP) Mixed lineage kinase 2 (MLK2) – MLK2 is myosin light chain kinase 2 The b2 adaptin of the AP2 complex Calcium-dependent activator protein for secretion (CADPS)
References
Further reading
External links NCS proteins