Locke may refer to:
People John Locke, English philosopher Locke (given name) Locke (surname), information about the surname and list of people
Places in the United States Locke, California, a town Locke, Indiana, an unincorporated community Locke, New York, a town Locke Island, in the Columbia River in Washington Locke Township, Michigan, a township Mount Locke, the site of the McDonald Observatory in the Davis Mountains of West Texas
Arts and entertainment Locke (film), a 2013 British film Locke the Superman, a 1980s manga series by Yuki Hijiri and its anime film adaptations
Fictional characters A family in the comic book series Locke & Key and its television series adaptation Jameson Locke, the protagonist of the video game Halo 5: Guardians John Locke (Lost), a character in the television series Lost Locke, a protagonist of the manga Locke the Superman Locke Cole, a character from the Final Fantasy VI video game Locke, the father of Knuckles the Echidna Locke Lamora, the protagonist of the novel The Lies of Locke Lamora Locke, pseudonym of Peter Wiggin in Ender’s Game by Orson Scott Card
Other uses Locke High School, Los Angeles, California