Benorilate (INN), or benorylate, is an ester-linked codrug of aspirin with paracetamol. It is used as an anti-inflammatory and antipyretic medication. In the treatment of childhood fever, it has been shown to be inferior to paracetamol and aspirin taken separately. In addition, because it is converted to aspirin, benorylate is not recommended in children due to concerns about Reye syndrome.
Synthesis Acetylsalicoyl chloride (1) condenses with paracetamol (2) to give benorilate (3).NL6504517 idem Andrew Robertson, (1969 to Sterling Drug Inc)Mario Portelli & Giorgio Renzi, (1974 to Whitefin Holding SA)Huang Xiaocheng, et al. (2020 to Guangxi University of Science and Technology)
Alkaline hydrolysis of the acetyl ester moiety of benorilate yields another pharmaceutical, acetaminosalol (phenetsal).
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