PLK may refer to:
PLK (rapper) (born 1997), French rapper of Polish and Corsican origin PKP PLK, a Polish railroad company PLK Vicwood KT Chong Sixth Form College Polska Liga Koszykówki, Polish Basketball League Polskie Linie Kolejowe, Polish railway infrastructure manager Pulkovo Airlines, ICAO airline designator M. Graham Clark Downtown Airport, Missouri, USA, IATA code Perfect Liberty Kyodan, a new religious movement Po Leung Kuk, a Hong Kong charitable organisation Polo-like kinase, regulators of the cell cycle (mitosis)
See also Polo-like kinase 1, an enzyme encoded by the PLK1 gene